| 发明名称 | Anti-cancer adenoviruses | ||
| 摘要 | Anti-cancer adenoviruses, methods of use and methods of making the same are provided herein. | ||
| 申请公布号 | US9187733(B2) | 申请公布日期 | 2015.11.17 |
| 申请号 | US201313768933 | 申请日期 | 2013.02.15 |
| 申请人 | Salk Institute for Biological Studies | 发明人 | O'Shea Clodagh;Powers Colin |
| 分类号 | A01N63/00;A61K48/00;C12N7/04;C12N7/00;A61K35/761 | 主分类号 | A01N63/00 |
| 代理机构 | Klarquist Sparkman, LLP | 代理人 | Klarquist Sparkman, LLP |
| 主权项 | 1. A method of treating a cancer with reduced expression or activity of p53, comprising administering an effective amount of a recombinant adenovirus that is E1B-55k impaired and E4-ORF3 impaired to a subject in need thereof, wherein the recombinant adenovirus is not replication impaired in a p53 impaired cell. | ||
| 地址 | La Jolla CA US | ||