Chemical compositions for enhancing transdermal delivery of therapeutic agents

摘要

The present application discloses chemical compositions and methods for enhancing the transdermal permeation of therapeutic agents through skin. The chemical compositions and methods of the invention can include combinations of a first fatty acid having about 14 or more carbon atoms and a second fatty acid having about 10 or less carbon atoms. These compositions are useful for the delivery of therapeutic agents, in particular hard to deliver drugs such as those that have fused rings, including ondansetron, and large drugs such as peptides. The compositions of the invention can be formulated as transdermal gels, lotions, creams, transdermal patches, sprays or mists.

主权项

1. A composition for use on human skin comprising:
a mixture comprising
ondansetron, an ondansetron salt, or a mixture thereof;from about 1% to about 5% by weight of the composition of oleic acid; andfrom about 1% to about 5% by weight of the composition of levulinic acid.