| 发明名称 |
Methods and compositions for alteration of skin pigmentation |
| 摘要 |
Compositions are provided that possess levels of phytic acid and optionally a hydroxy acid and/or azelaic acid that act synergistically with the phytic acid to reduce melanin levels in skin. Improved reduction in melanin levels and hyperpigmentation are achieved at low levels of azelaic acid and phytic acid such that greater comfort and reduced irritation are observed at an administration site. Processes of reducing melanin levels or treating hyperpigmentation are provided by topically administering compositions of the invention. |
| 申请公布号 |
US9186310(B2) |
申请公布日期 |
2015.11.17 |
| 申请号 |
US201214363920 |
申请日期 |
2012.03.16 |
| 申请人 |
|
发明人 |
Kulesza John E. |
| 分类号 |
A61K8/00;A61K8/18;A61K8/55;A61K31/192;A61K31/455;A61K31/19;A61K31/194;A61K31/6615;A61K8/362;A61Q19/02;A61K9/00;A61K8/365;A61K8/67 |
主分类号 |
A61K8/00 |
| 代理机构 |
Dinsmore & Shohl LLP |
代理人 |
Dinsmore & Shohl LLP ;Gould Weston R. |
| 主权项 |
1. A composition for promoting a reduction in skin pigmentation comprising:
azelaic acid at 0.1 to 1.5 percent by weight, azelaic acid is alone or in combination with one or more hydroxy acids; and phytic acid present at 0.1 to 8 percent by weight; wherein said azelaic acid and said phytic acid are present in synergistic concentrations to reduce melanin levels in a melanin containing cell when contacted to said cell. |
| 地址 |
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