Establishment of rhesus monkey model of autoimmunity type 1 diabetes

摘要

Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.

主权项

1. A method of preparing a rhesus monkey model for screening drugs for treatment of autoimmune type 1 diabetes, the method comprising:
intravenously administering streptozotocin to a rhesus monkey at a dose of 20-30 mg/kg per injection per diem for 5 consecutive days, the first injection being given on day 1; and intravenously administering streptozotocin to the rhesus monkey at a dose of 20-30 mg/kg per injection per diem on the 12th day and the 19th day after day 1 of the 5-day administration, wherein the rhesus monkey exhibits a fasting glucose level greater than 11.1 mmol/L, a C-peptide level less than 0.3 nM, and has anti-islet cell antibodies and anti-insulin antibodies.