Compositions containing nucleosides and manganese and their uses

摘要

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

主权项

1. A method of protecting mammalian cells from ionizing radiation-induced damage, the method comprising administering a protective amount of a protein-free D. radiodurans ultrafiltrate to the mammalian cells, wherein the ultrafiltrate does not contain molecules having a molecular weight of greater than 3 kDa.