Method for preparing largazole analogs and uses thereof

摘要

Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

主权项

1. A compound of Formula (I) wherein X is S or O; Y is NR, wherein R is H, lower alkyl, or lower arylalkyl; Z is S or O; R1 is H, lower alkyl, or lower arylalkyl; R2 is lower alkyl, isopropyl, n-propyl, cyclopropyl, isobutyl, n-butyl, sec-butyl, or tert-butyl; R4 is H, (CH2)nCOOH, (CH2)nCONHR, (CH2)nCONHOH, (CH2)nSR3, SR5 (wherein R5 is lower alkyl or lower aryl),wherein n is at least 1, and wherein R3 is H, octanoyl, acyl, SR, a higher acyl derivative, or or a pharmaceutically acceptable salt, solvate, clathrate, prodrug, or stereoisomer thereof.