| 发明名称 | Methods for treating frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) | ||
| 摘要 | Methods for rescuing learning, memory and/or motor function deficits associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are disclosed. The method comprises: a) administering to an animal having FTLD-U a therapeutically effective amount of an autophagy inducer; b) causing a decrease in the amount of ubiquitinated TDP-43 aggregation forms in the brain of the animal; and c) causing an improvement of the learning, memory capacities and/or motor function of the animal. | ||
| 申请公布号 | US9186356(B2) | 申请公布日期 | 2015.11.17 |
| 申请号 | US201213343686 | 申请日期 | 2012.01.04 |
| 申请人 | Academia Sinica | 发明人 | Shen Che-Kun James;Tsai Kuen-Jer |
| 分类号 | A61K31/4436;A61K31/132;A61K31/138;A61K31/513;A61K31/55;A61K31/7016;A61K31/4433 | 主分类号 | A61K31/4436 |
| 代理机构 | Intellectual Property Connections, Inc. | 代理人 | Saunders Hsiu-Ming;Intellectual Property Connections, Inc. |
| 主权项 | 1. A method of alleviating and/or rescuing a motor function deficit associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) comprising: administering to an animal in need of alleviating and/or rescuing the motor function deficit associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) a therapeutically effective amount of rapamycin, and thereby alleviating and/or rescuing the motor function deficit associated with the FTULD-U, wherein the animal has an early stage of frontotemporal lobar degeneration without exhibiting ubiquitinated inclusions in the forebrain thereof. | ||
| 地址 | Taipei TW | ||