Controlled-release melatonin compositions and related methods

摘要

A melatonin-containing product includes a composition comprising melatonin, a pH lowering agent, and a gel-forming forming polymer. When ingested, the composition forms an acidic aqueous gel matrix having melatonin dissolved therein for releasing melatonin into the intestines for a sustained time period.

主权项

1. A controlled-release melatonin-containing product comprising:
a composition comprising melatonin, a pH lowering agent, and a gel-forming forming polymer that, when said composition is ingested, forms an aqueous gel matrix having melatonin dissolved therein and an internal pH of less than 4.4 in said aqueous gel matrix, wherein
said composition provides a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep; andsaid composition is effective to release approximately 50% of said melatonin in said composition into the gastrointestinal tract within approximately two hours after oral ingestion.