Active nanoparticles and method of using

摘要

Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

主权项

1. A method of transporting a drug to a target bacterial infection of epithelial tissue in a patient's body where access to the target bacterial infection site is impaired by the presence of a biological barrier comprising at least one of a mucus barrier, an alginate barrier and a microbial biofilm barrier, comprising administering a plurality of magnetic nanoparticles adjacent to the biological barrier, said magnetic nanoparticles carrying a drug, and providing a nanoparticle-moving magnetic field proximate to the target bacterial infection site in a manner that transports the plurality of drug-carrying nanoparticles to traverse through the barrier to reach the target bacterial infection site.