Glycoprotein hormone long-acting superagonists

摘要

This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type counterparts. The analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity.

主权项

1. A modified bovine follicle-stimulating hormone (FSH) comprising SEQ ID NO: 2 with arginine, histidine, or lysine substitutions at K15, K17, K20, K24 and E18 and an insert of SEQ ID NO: 1 between F6 and T7, wherein the modified bovine FSH has an increased FSH receptor activation compared to bovine wild type FSH.