| 主权项 |
1. A tricyclic compound represented by:and wherein:
A is phenyl;RA1 is selected, independently for each occurrence, from the group consisting of: hydrogen, hydroxy, cyano, halogen, C1-4alkyl, and C1-3alkoxy; wherein C1-4alkyl or C1-3alkoxy may be optionally substituted by one or more fluorines;n is 1 or 2;RA2 is selected from the group consisting of: hydrogen, RiRjN—, heterocyclyl, heterocyclyloxy, and heterocyclyl-(NRa)—; wherein said heterocyclyl may optionally be substituted by one or more substituents selected from Rg; and wherein if said heterocyclyl contains a —NH moiety that nitrogen may optionally be substituted by one or more groups Rh; orRA2 may be selected from the group consisting of: C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C3-6alkenyloxy, C3-6alkynyloxy, C3-6cycloalkoxy, C1-6alkyl-S(O)w— (wherein w is 0, 1 or 2), C1-6alkyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-, C1-6alkylcarbonyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-N(Ra)—, C1-6alkyl-N(Ra)—SO2—, C1-6alkyl-SO2—N(Ra)—, C1-6alkoxycarbonyl-N(Ra)—, C1-6alkylcarbonyl-N(Ra)—C1-6alkyl-, C1-6alkyl-N(Ra)-carbonyl-C1-6alkyl-, and C1-6alkoxyC1-6alkyl-; wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C3-6alkenyloxy, C3-6alkynyloxy, C3-6cycloalkoxy, C1-6alkyl-S(O)w—, C1-6alkyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-, C1-6alkylcarbonyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-N(Ra)—, C1-6alkyl-N(Ra)—SO2—, C1-6alkyl-SO2—N(Ra)—, C1-6alkoxycarbonyl-N(Ra)—, C1-6alkylcarbonyl-N(Ra)C1-6alkyl-, C1-6alkyl-N(Ra)-carbonyl-C1-6alkyl-, C1-6alkoxy-C1-6alkyl may optionally be substituted by RP, phenyl, phenoxy, heteroaryl, heteroaryloxy, heteroaryl-(NRa)—, heterocyclyl, heterocyclyloxy or heterocyclyl-N(Ra)—; and wherein said heteroaryl or phenyl may optionally be substituted with one or more substituents selected from Rf; and wherein said heterocyclyl may optionally be substituted by one or more substituents selected from Rg; and wherein if said heterocyclyl contains a —NH moiety that nitrogen may optionally be substituted by one or more groups Rh;Ra and Rb are independently selected, for each occurrence, from the group consisting of: hydrogen and C1-3alkyl; wherein C1-3alkyl may optionally be substituted by one or more substituents selected from the group consisting of: fluorine, cyano, oxo, and hydroxy;or Ra and Rb, together with the nitrogen to which they are attached, may form a 4-6 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N; wherein the 4-6 membered heterocyclic ring may optionally be substituted on carbon by one or more substituents selected from the group consisting of: fluorine, cyano, oxo, and hydroxy;Rf is independently selected, for each occurrence, from the group consisting of: RP, hydrogen, C1-6alkyl, C3-6cycloalkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkyl-S(O)w— (wherein w is 0, 1 or 2), C1-6alkylcarbonl-N(Ra)—, and C1-6alkoxycarbonyl-N(Ra)—; wherein C1-6alkyl, C3-6cycloalkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkyl-S(O)w—, C1-6alkylcarbonyl-N(Ra)—, or C1-6alkoxycarbonyl-N(Ra)— may be optionally substituted by one or more substituents selected from RP;Rg is independently selected for each occurrence from the group consisting of: RP, hydrogen, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkyl-S(O)w— (wherein w is 0, 1 or 2), C1-6alkylcarbonyl-N(Ra)—, and C1-6alkoxycarbonyl-N(Ra)—; wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-3cycloalkyl, C1-6alkoxy, C1-6 alkyl-S(O)w—, C1-6alkylcarbonyl-N(Ra)—, or C1-6alkoxycarbonyl-N(Ra)— may be optionally substituted by one or more substituents selected from RP;Rh is independently selected for each occurrence from the group consisting of: hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl, C1-6alkyl-S(O)2—, C1-6alkoxycarbonyl-, RiRjN-carbonyl-, RiRjN—SO2—; wherein C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl, C1-6alkyl-S(O)2—, C1-6alkylcarbonyl- may optionally be substituted by one or more substituents selected from RP;Ri and Rj are selected independently for each occurrence from the group consisting of: hydrogen, C1-4alkyl and C3-6cycloalkyl; wherein C1-4alkyl and C3-6cycloalkyl may be optionally substituted by one or more substituents selected from fluorine, hydroxyl, cyano, RaRbN—, RaRbN-carbonyl-, C1-3alkoxy;or Ri and Rj taken together with the nitrogen to which they are attached may form a 4-7 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N, optionally substituted on carbon by one or more substituents selected from the group consisting of: fluorine, hydroxyl, oxo, cyano, C1-6alkyl, C1-6alkoxy, RaRbN—, RaRbN—SO2—, and RaRbN-carbonyl-; and wherein said C1-6alkyl or C1-6alkoxy may optionally be substituted by fluorine, hydroxyl or cyano; and optionally substituted on nitrogen by one or more substituents selected from the group consisting of: C1-6alkyl, RaRbN-carbonyl-; and wherein said C1-6alkyl may be optionally substituted by fluorine, hydroxyl, cyano;RP is independently selected, for each occurrence, from the group consisting of: halogen, hydroxyl, cyano, C1-6alkoxy, RiRjN—, RiRjN-carbonyl-, RiRjN—SO2—, RiRjN-carbonyl-N(Ra)—;and pharmaceutically acceptable salts and stereoisomers thereof. |
