| 主权项 |
1. A compound of the following formula (I): wherein: A is aryl; B is selected from the group consisting of —NR2 and —(C═O)—; C is selected from the group consisting of —(C═O)— and —NR2; R1 is independently selected from the group consisting of:
(1) hydrogen, (2) —On—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (3) —On—C3-7 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (4) —On-aryl, where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11, (5) —S—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (6) —S-aryl, where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11, (7) —NH—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, and (8) —NH-aryl, where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11; R2 is independently selected from the group consisting of:
(1) hydrogen, (2) a halogen selected from the group consisting of chlorine, bromine, and fluorine, (3) hydroxyl, (4) —On—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (5) —On—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (6) —On—C2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R7, (7) —On-phenyl or —On-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R7, (8) —On-heterocyclyl, where the heterocyclyl is unsubstituted or substituted with one or more substituents independently selected from R7, (9) —(C═O)—NR8R9, (11) —S(O)2—NR8R9, (12) —NR8—S(O)2R9, (13) —S(O)t—R9, where t is 0, 1 or 2, (14) —NR8(C═O)R9, (15) —CN, and (16) —NO2;
wherein n is independently 0 or 1, and when n is 0, a chemical bond is present in the place of —On—; p is 1, 2, 3 or 4; when p is two or more than two, R2 may be the same or different; R3 and R4 are independently hydrogen or C1-6 alkyl which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, and —O—C1-6 alkyl; or R3 forms a 3 to 7 membered ring with R4 which may contain a nitrogen atom, an oxygen atom, a sulfur atom or a double bond,
wherein the 3 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydrogen, (2) hydroxyl, (3) halogen, (4) C1-6 alkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (5) C3-6 cycloalkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (6) —O—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, and (7) —O—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one ore more substituents independently selected from R11; R5 is independently selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) —On—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (4) —On—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R7, and (5) —On—C2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R7;
wherein n is independently 0 or 1, and when n is 0, a chemical bond is present in the place of —On—; and R5 may be substituted anywhere on the pyrrolopyridinone ring; q is 1, 2 or 3; and when q is two or more than two, R5 may be the same or different; R6 is independently hydrogen, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C3-7 cycloalkyl, —NR8R9, heterocyclyl, aryl, aryl-C1-6 alkyl, or heterocyclyl-C1-6 alkyl,
wherein the C1-6 alkyl, the C1-6 alkoxy, the C2-6 alkenyl, the C3-7 cycloalkyl, the heterocyclyl, the aryl, the aryl-C1-6 alkyl, or the heterocyclyl-C1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, —O—C1-6 alkyl, —C3-7 cycloalkyl, —O—C3-7 cycloalkyl, hydroxyl-C1-6 alkoxy, —CN, —NR8R9, —(C═O)—R8, —(C═O)—NR8R9, —NR8—(C═O)—R9, —NR8—(C═O)—NR9R10, and —(C═O)—, or R6 may form a 4-7 membered ring with R2; R7 is selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) hydroxyl, (4) —(C═O)m—Ol—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (5) —Ol—(C1-3)perfluoroalkyl, (6) —(C═O)m—Ol—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (7) —(C═O)m—Ol—C2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R11, (8) —(C═O)m—Ol-phenyl or —(C═O)m—Ol-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R11, (9) —(C═O)m—Ol-heterocyclyl, where the heterocyclyl is unsubstituted or substituted with one or more substituents independently selected from R11, (10) —(C═O)—NR8R9, (12) —S(O)2—NR8R9, (13) —S(O)t—R8, where t is 0, 1 or 2, (14) —CO2H, (15) —CN, and (16) —NO2;
wherein l is 0 or 1, and m is 0 or 1;when l is 0 or m is 0, a chemical bond is present in the place of —Ol— or —(C═O)m—, and when l is 0 and m is 0, a chemical bond is present in the place of —(C═O)m—Ol—; R8, R9, and R10 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, aryl, heterocyclyl, aryl-C1-6 alkyl, or heterocyclyl-C1-6 alkyl, where the C1-6 alkyl, the C2-6 alkenyl, the C3-7 cycloalkyl, the aryl the heterocycclyl, the aryl-C1-6 alkyl, or the heterocyclyl-C1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, —O—C1-6 alkyl, C3-7 cycloalkyl, —O—C3-7 cycloalkyl, trifluoromethyl, and trifluoromethoxy; or R8 forms a 4 to 7 membered ring with R9 which may contain a nitrogen atom, an oxygen atom, a sulfur atom or a double bond,
wherein the 4 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydrogen, (2) hydroxyl, (3) halogen, (4) C1-6 alkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (5) C3-6 cycloalkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (6) —O—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, and (7) —O—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11; R11 is independently selected from the group consisting of:
(1) hydrogen, (2) hydroxyl, (3) halogen, (4) —C1-6 alkyl, which is unsubstituted or substituted with one or more halogens, (5) —C3-6 cycloalkyl, (6) —O—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more halogens, (7) —O(C═O)—C1-6 alkyl, (8) —NH—C1-6 alkyl, (9) phenyl, (10) heterocyclyl, (11) —CN, and (12) —Si(C1-6 alkyl)3; and k is 1; or a prodrug thereof or a pharmaceutically acceptable salt thereof. |
