Nanoparticles containing pH-responsive peptide

摘要

The present invention provides a nanoparticle and cell delivery agent, capable of releasing a target substance in a weakly acidic pH environment. Specifically, the present invention provides a nanoparticle comprising a peptide and a particle-forming component, the particle-forming component forming a liposome or a micelle, the peptide having a sequence with 2 to 8 units starting with His (histidine) and ending with an acidic amino acid, wherein each of the units may be identical or different.

主权项

1. A peptide compound represented by Formula (II) below:
R1—(Z1)l-[His-(AA1)(AA2)(AA3)-Glu/Asp]n-(Z2)m—R2  (II), wherein His is histidine; Glu/Asp is a glutamic acid or aspartic acid; AA1, AA2, and AA3 are the same or different and each represent Gly, Ala, His, Leu, Ile, Val, Phe, Tyr, Trp, Cys, Met, Ser, Thr, Gln, or Asn; n represents an integer of 2 to 8; l and m are the same or different and each represent 0 or 1; R1 is a C12-24 hydrocarbon or a C12-24 acyl group; R2 is OH or a C-terminal protecting group; and Z1 and Z2 each represent a linker consisting of 1 to 8 amino acids selected from Gly, Ala, Leu, Ile, Val, Phe, Tyr, Trp, Cys, Met, Ser, Thr, Gln, and Asn, the peptide compound containing 10 to 60 amino acids in total.