| 发明名称 |
Method for preparing nilotinib |
| 摘要 |
The present invention provides a method for preparing Nilotinib of the following structure:;
by direct condensation of an ester and an aniline promoted by trialkyl aluminum in an organic solvent. |
| 申请公布号 |
US9187452(B1) |
申请公布日期 |
2015.11.17 |
| 申请号 |
US201414479318 |
申请日期 |
2014.09.07 |
| 申请人 |
FORMOSA LABORATORIES, INC. |
发明人 |
Hung Jui-Te;Chen Wen-Chin |
| 分类号 |
C07D401/14 |
主分类号 |
C07D401/14 |
| 代理机构 |
|
代理人 |
Tien Hannah M. |
| 主权项 |
1. A method for preparing Nilotinib of the following structure: comprising reacting an ester of the following structure:with an aniline 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine of the following structure:wherein R is lower alkyl, phenyl, phenyl-lower alkyl or substituted phenyl,wherein the reaction is promoted by a trialkyl aluminum compound in an organic solvent. |
| 地址 |
Taoyuan TW |
