Solubility enhancer and use thereof

摘要

Disclosed herein is a novel solubility enhancer capable of being employed in formulating safe and effective pharmaceutical formulations of partially soluble drugs, wherein the solubility enhancer is selected from dialkyl substituted amides of fatty acids having C6 to C16 carbon chain, preferably from N,N-dimethyl hexanamide, N,N-dimethyl octanamide, N,N-dialkyl decanamide, N,N-dialkyl dodecanamide or N,N-dialkyl hexadecanamide.

主权项

1. A clear solution consisting essentially of:
a drug that is insoluble or partially soluble in an aqueous medium used for humans or animals; a solubilizer, wherein said solubilizer is a single N,N-dialkylamide of an aliphatic carboxylic acid selected from the group consisting of N,N-dimethyl hexanamide, N,N-dimethyl octanamide, N,N-dimethyl decanamide, and N,N-dimethyl dodecanamide; and optionally a surfactant.