NOTCH-BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF
摘要
THE PRESENT INVENTION RELATES TO NOTCH-BINDING AGENTS AND NOTCH ANTAGONISTS AND METHODS OF USING THE AGENTS AND/OR ANTAGONISTS FOR TREATING DISEASES SUCH AS CANCER. THE PRESENT INVENTION PROVIDES ANTIBODIES THAT SPECIFICALLY BIND TO A NON-LIGAND BINDING REGION OF THE EXTRACELLULAR DOMAIN OF ONE OR MORE HUMAN NOTCH RECEPTOR, SUCH AS NOTCH2 AND/OR NOTCH3, AND INHIBIT TUMOR GROWTH. THE PRESENT INVENTION FURTHER PROVIDES METHODS OF TREATING CANCER, THE METHODS COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANTIBODY THAT SPECIFICALLY BINDS TO A NON-LIGAND BINDING REGION OF THE EXTRACELLULAR DOMAIN OF A HUMAN NOTCH RECEPTOR PROTEIN AND INHIBITS TUMOR GROWTH.
申请公布号
MY155603(A)
申请公布日期
2015.11.13
申请号
MY2011PI00058
申请日期
2009.07.08
申请人
ONCOMED PHARMACEUTICALS, INC.
发明人
GURNEY, AUSTIN L.;HOEY, TIMOTHY CHARLES;HTUN VAN DER HORST, EDWARD THEIN;SATO, AARON KEN;LIU, YUAN CHING;BRUHNS, MAUREEN FITCH;LEWICKI, JOHN A.