OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR THE USE IN MODULATION OF MICRORNAS

摘要

Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activating in a cell.

主权项

1. An oligomeric compound comprising a contiguous sequence of about 17 to about 29 nucleosides linked by internucleoside linking groups, said sequence having an internal region located between two external regions, each external region independently comprises from 1 to about 3 nucleosides, each external region comprises a stabilizing modification, and the internal region comprises at least 10 β-D-2′-deoxy-2′-fluororibofuranosyl nucleosides.