| 发明名称 |
ANTI-PD-L1 ANTIBODIES AND ARTICLES OF MANUFACTURE |
| 摘要 |
The present application relates to anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity. |
| 申请公布号 |
US2015322153(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201414538072 |
申请日期 |
2014.11.11 |
| 申请人 |
GENENTECH, INC. |
发明人 |
IRVING Bryan;CHIU Henry;MAECKER Heather;MARIATHASAN Sanjeev;LEHAR Sophie M.;WU Yan;CHEUNG Jeanne |
| 分类号 |
C07K16/28;A61K39/395;C07K16/30;A61K45/06;A61K31/7068 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated heavy chain variable region polypeptide comprising an HVR-H1, HVR-H2 and HVR-H3 sequence, wherein:
(a) the HVR-H1 sequence is GFTFSX1SWIH (SEQ ID NO:1); (b) the HVR-H2 sequence is AWIX2PYGGSX3YYADSVKG (SEQ ID NO:2); (c) the HVR-H3 sequence is RHWPGGFDY (SEQ ID NO:3); further wherein: X1 is D or G; X2 is S or L; X3 is T or S. |
| 地址 |
SOUTH SAN FRANCISCO CA US |
