| 发明名称 |
METHODS FOR THE PREVENTION OR TREATMENT OF SCOLIOSIS |
| 摘要 |
A method for the prevention or treatment of scoliosis in a human subject comprising: (a)(i) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject over time; or (ii) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject and comparing the OPN protein expression to an OPN protein expression in a control biological fluid sample; (b) identifying the subject as being at risk of developing scoliosis when OPN protein expression increases in the subject sample over time; or when OPN protein expression is higher in the subject sample than that in the control sample; and (c) reducing OPN protein levels in the subject identified as being at risk of developing a scoliosis, thereby aiding in the prevention or treatment of scoliosis. |
| 申请公布号 |
US2015323553(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514807450 |
申请日期 |
2015.07.23 |
| 申请人 |
CHU Sainte-Justine |
发明人 |
Moreau Alain |
| 分类号 |
G01N33/68;A61F5/01;A23L1/29;A61K33/04 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the prevention or treatment of scoliosis in a human subject, comprising:
(a) (i) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject over time; or
(ii) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject and comparing the OPN protein expression to an OPN protein expression in a control biological fluid sample; (b) identifying the subject as being at risk of developing scoliosis when OPN protein expression increases in the subject sample over time; or when OPN protein expression is higher in the subject sample than that in the control sample; and (c) reducing OPN protein levels in the subject identified as being at risk of developing a scoliosis, thereby aiding in the prevention or treatment of scoliosis. |
| 地址 |
Montreal CA |
