METHOD FOR TREATING A DISEASE ASSOCIATED WITH SOLUBLE, OLIGOMERIC SPECIES OF AMYLOID BETA 1-42

摘要

This invention is a method and kit for treating a disease associated with, or resulting from, the accumulation of soluble oligomer amyloid beta 1-42 using an antibody, or antibody fragment thereof, that has a higher affinity for amyloid beta 1-42 oligomers than for amyloid beta 1-42 monomer, amyloid beta 1-40 monomer, plaques and amyloid beta fibrils, wherein the antibody is in combination with a tau therapeutic or an inhibitor of amyloid beta production or aggregation.

主权项

1. A method for treating a disease associated with or resulting from the accumulation of soluble oligomer amyloid beta 1-42 comprising administering to a subject in need thereof
(a) a dose of less than 10 mg/kg body weight of an antibody, or antibody fragment thereof, that has a higher affinity for amyloid beta 1-42 oligomers than for amyloid beta 1-42 monomer, amyloid beta 1-40 monomer, plaques and amyloid beta fibrils; and (b) a second therapeutic comprising
(i) a beta-secretase or gamma-secretase inhibitor,(ii) an amyloid beta aggregation inhibitor,(iii) a tau therapeutic, or(iv) a combination of (i)-(iii).so that the disease associated with or resulting from the accumulation of soluble oligomer amyloid beta 1-42 is treated.