摘要 |
A method of making a recombinant adenovirus, comprising assembling an adenovirus genome bycombining a hybridization competent adenoviral destination vector with one or more hybridization competent adenoviral gene modules by sequence and ligation independent cloning (SLIC), wherein the one or more hybridization competent adenoviral gene modules comprise an E2 L2 module, an L3-L4 module, an E2-L4 module, an El module, an E3 module, an E4 module, or any combination thereof. |