Mutant interleukin-2 polypeptides

摘要

Abstract The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the a-subunit of the IL-2 receptor, for use as immunotherapeutic 5 agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof 7046133_1 (GHMatters) P93282.AU.1 LEOWNR