发明名称 |
O-ACETYLATED HIGH MOLECULAR WEIGHT POLYGALACTURONIC ACIDS AND THEIR USE AS VI POLYSACCHARIDE VACCINE |
摘要 |
The instant disclosure provides O-acetylated high molecular weight polygalacturonic acids or pharmaceutically acceptable salts thereof, having at least one of: (a) a molecular weight greater than 1 x 106 Da; (b) a degree of mefhylation less than about 10% per mole; and (c) an intervening rhamnose content ranging from about 2% to about 15% per mole, useful as a synthetic immunogenic Vi antigen. The instant disclosure further provides methods of preparing an O-acetylated high molecular weight polygalacturonic acid or pharmaceutically acceptable salt thereof of, pharmaceutical compositions and/or vaccine compositions comprising the same, and methods of immunization using any of the foregoing. |
申请公布号 |
CA2946900(A1) |
申请公布日期 |
2015.11.12 |
申请号 |
CA20152946900 |
申请日期 |
2015.05.08 |
申请人 |
NANOTHERAPEUTICS, INC. |
发明人 |
NI, YAWEI;SPRINGER, MICHAEL |
分类号 |
C08B37/06;A61K31/732;A61K39/00;A61P31/04;A61P37/04 |
主分类号 |
C08B37/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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