REHYDRATABLE PHARMACEUTICAL PRODUCT

摘要

A pharmaceutical product comprising lyophilised polymer matrix including a biologically active compound, of particular utility for embolisation, having improved rehydration properties is packaged in an airtight package under vacuum.

主权项

1. A method for formulating a dried packaged product suitable for direct administration to an animal after rehydration to form a suspension comprising:
i) providing particles of polymer matrix swollen with water and having absorbed therein a non-volatile biologically active compound; ii) cooling the swollen articles from step i) in a freezing step to a temperature below the freezing point for water; iii) in a lyophilisation step subjecting the cooled particles from step ii) to a reduced pressure at which ice sublimes for a period during which at least a portion of the absorbed ice sublimes and water vapour is removed; and iv) in a packaging step, packaging the dried particles under reduced pressure and into a package that is substantially airtight and has an interior under vacuum to form packaged particles.