发明名称 |
CYCLOHEXYL-PYRIDINE DERIVATIVE |
摘要 |
Provided is a novel compound which has an NK1 receptor antagonistic action and which is useful in the prevention and treatment of nausea and vomiting accompanying the administration of antineoplastic drugs, which have a diminished CYP3A4 inhibitory action compared to aprepitant. That is to say, the present invention pertains to a cyclohexyl-pyridine derivative represented by formula (I), or a pharmacologically acceptable salt thereof. In the formula, ring A is 4-fluoro-2-methyl phenyl or the like, X is a hydrogen atom or the like, R1 is a carboxymethyl or the like, R2 is an alkyl or the like, Y is from 0-2 or the like, U is -N(CH3)COC(CH3)2-3,5-bis(trifluoromethyl)phenyl or the like. |
申请公布号 |
WO2015170693(A1) |
申请公布日期 |
2015.11.12 |
申请号 |
WO2015JP63154 |
申请日期 |
2015.05.07 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
SHIMIZU, KAZUO;OHNO, KOHSUKE;MIYAGI, TAKASHI;UENO, YASUNORI;SUZUKI, HIKARU |
分类号 |
C07D213/75;A61K31/4418;A61P1/08;C07D213/76;C07D213/84 |
主分类号 |
C07D213/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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