发明名称 |
HUMANIZED IL-4 AND IL-4R ALPHA ANIMALS |
摘要 |
Non-human animals comprising a human or humanized IL-4 and/or IL-4R nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R gene with a human IL-4 gene and/or IL-4R gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R gene under control of non-human IL-4R regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R -encoding sequence with human or humanized IL-4R -encoding sequence at an endogenous non-human C IL-4R locus. Non-human animals comprising human or humanized IL-4 gene and/or IL-4R sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided. |
申请公布号 |
WO2015171861(A1) |
申请公布日期 |
2015.11.12 |
申请号 |
WO2015US29638 |
申请日期 |
2015.05.07 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
WANG, LI-HSIEN;XUE, YINGZI;MURPHY, ANDREW J.;STEVENS, SEAN |
分类号 |
A01K67/027;C07K14/54;C07K14/715 |
主分类号 |
A01K67/027 |
代理机构 |
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