| 摘要 |
The invention features methods of treating subjects for inflammatory conditions, such as mild traumatic brain injury (mTBI), osteoarthritis (OA), and fibromyalgia. The method may involve determining if the subject has such an inflammatory condition and administering an effective amount of a tetracycline compound (e.g., doxycycline) to the subject (e.g., a human). The invention also features methods for detecting an inflammatory condition in a subject by determining a level of an inflammatory biomarker, such as TGF-βΙ, in a biological sample (e.g., blood) obtained from the subject. Such methods can also be used as a companion diagnostic in combination with tetracycline treatment to assess treatment efficacy. The invention further features kits for detecting and treating such inflammatory conditions. |
