| 摘要 |
Non-human animals (a) and (b) are highly useful as a model for hyperuricemia. (a) A non-human animal obtained by transplanting human hepatic cells into a non-human animal with an immunodeficient hepatic disorder to obtain a primary chimera non-human animal, and then administering a purine base-containing substance to this primary chimera non-human animal to obtain the non-human animal. (b) A non-human animal obtained by performing a first step in which human hepatic cells are transplanted into a non-human animal with an immunodeficient hepatic disorder to obtain a primary chimera non-human animal, and a second step in which the human hepatic cells grown inside the primary chimera non-human animal are transplanted into a non-human animal having an immunodeficient hepatic disorder, and the second step is performed one or more times to obtain a passage chimera non-human animal, to which a purine base-containing substances is administered to obtain a non-human animal. |
