POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME

摘要

Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.

主权项

1. A β-polypeptide comprising internal summits having a structure selected from the group consisting of:wherein R3, R4, R5, and R6 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C6-alkyl, aryl, C1-C6-alklyaryl, amino, protected-amino, amino-C1-C6-alkyl, and protected-amino-C1-C6-alkyl; andwherein A together with the carbon atoms to which it is attached is selected from the group consisting of substituted or unsubstituted C5-C12 cycloalkyl, C5-C12 cycloalkenyl, and five- to twelve-membered heterocyclic.