| 发明名称 |
MEANS AND METHODS FOR TREATING CMV |
| 摘要 |
The present invention relates to the field of recombinant protein production and vaccine preparation. In particular, the invention provides means and methods for producing the pentameric gH/gL/UL128/UL130/UL131A complex of CMV. More specifically, the invention provides a pentameric gH/gL/UL128/UL130/UL131A complex of CMV produced in a baculovirus system which can be used as a vaccine against CMV. |
| 申请公布号 |
US2015322115(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514708081 |
申请日期 |
2015.05.08 |
| 申请人 |
REDVAX GMBH |
发明人 |
Wellnitz Sabine;John Corinne;Schaub Christian |
| 分类号 |
C07K14/005;C12N7/00;C12N15/86;A61K39/245 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pentameric complex composed of CMV proteins UL128, UL130, UL131A, gH (UL75) and gL (UL115) obtainable by the method, comprising
(i) co-expressing CMV proteins UL128, UL130, UL131A, gH (UL75) and gL (UL115) in a host cell by using baculovirus; (ii) purifying the pentameric complex from host cells and/or supernatant obtained from said co-expression; and (iii) storing the purified pentameric complex in a buffer solution comprising a chelating agent and/or a stabilizing agent. |
| 地址 |
Schlieren CH |
