METHOD OF TREATING ADVANCED NON-ALCOHOLIC STEATOHEPATITIS

摘要

A compound of Formula (I):;;or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting or treating advanced nonalcoholic steatohepatitis, conditions leading to or arising from it, and/or negative effects of each thereof.

主权项

1. A method of treating a patient diagnosed with advanced non-alcoholic steatohepatitis (NASH), the method comprising administering to the patient an effective amount of a compound of Formula (I), a metabolite of the compound of Formula (I), an ester of the compound of Formula (I), or a metabolite of the ester of the compound of Formula (I): or a pharmaceutically acceptable salt of each of the foregoing, wherein m is an integer from 2 to 5 inclusive, and n is an integer from 3 to 8 inclusive, X1 and X2 each independently represent sulfur, oxygen, a sulfinyl group or a sulfonyl group, provided that X1 and X2 are not simultaneously oxygen.