| 发明名称 |
Methods and Compositions of Improved Modified siRNA |
| 摘要 |
Chemically modified small interfering RNAs (siRNAs) that include both phosphorodithioate modifications (PS2-RNA) and 2′-O-methyl modifications (MePS2) provide improved RNA silencing. Specific chemically modified siRNA that show enhanced silencing of RNAs involved in resistance to chemotherapeutic agents are provided. |
| 申请公布号 |
US2015322431(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514645351 |
申请日期 |
2015.03.11 |
| 申请人 |
AM Biotechnologies LLC |
发明人 |
Yang Xian-bin |
| 分类号 |
C12N15/113;A61K31/713;A61K45/06 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A chemically modified siRNA comprising a combination of 2′-OMe and PS2 modifications on either or both sense and antisense strands that improve serum stability and gene silencing efficacy. |
| 地址 |
Houston TX US |
