AUTOMATION OF INCUBATION, PROCESSING, HARVESTING AND ANALYSIS OF SAMPLES IN A MULTI-CELL PLATE WITH THIN FILM SAMPLE SUPPORT

摘要

The present invention relates to the automation of incubation, processing, harvesting and analysis of samples (15) in a multi-cell plate (1). In particular, a multi-cell plate (1) comprising a body (3) with a plurality of cells (5) is presented. Furthermore, an automated crystal harvesting and processing system (21) with a cutting unit (23), a fluid unit (29) and a removing device (33) is presented. The multi-cell plate (1) further comprises a sealing film (7) for sealing the cells (5) on a first side (9) of the body (3) and a sample film (11) for sealing the cells (5) on a second side (13) of the body (3). The sample film (11) is adapted for accommodating a biological material (15) for crystallization. Furthermore, the sample film (11) is of a thickness and composition that makes it compatible with x-rays and also with laser ablation. The design of the multi-cell plate (1) and the automated crystal harvesting and processing system (21) allows for several steps of incubation, processing, harvesting and analysis of the samples (15) to be automated.

主权项

1. Multi-cell plate for automated incubation, processing harvesting and analysis of samples of biological material, the multi-cell plate comprising
a body with a plurality of cells; a sealing film for sealing the cells on a first side of the body; a sample film for sealing the cells on a second side of the body; wherein the sample film is adapted for accommodating a biological material for crystallization; wherein the sample film comprises a material compatible with laser-induced photo ablation and/or compatible with X-ray data collection.