| 摘要 |
The invention relates to indole carboxamide derivatives of formula (I),;;wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds. |
| 主权项 |
1. A compound of the formula (I),wherein
R1 represents a heteroaryl or an aryl group which groups are independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C1-C4)alkyl, (C3-C6)cycloalkyl, (C1-C4)alkoxy, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, hydroxy, halogen and phenoxy; R2 represents
heterocyclyl which is unsubstituted, mono- or di-substituted, wherein the substituents are independently selected from (C1-C4)alkyl, (C1-C4)alkylcarbonyl, (C1-C4)alkoxycarbonyl, (C1-C4)alkylsulfonyl, and halogen;heterocyclyloxy;(C3-C6)cycloalkyl which is unsubstituted or mono- or di-substituted with halogen;(C3-C6)cycloalkyloxy;N—(C3-C6)cycloalkyl-amino;N—(C3-C6)cycloalkylmethyl-amino;(C3-C6)alkyl;(C2-C6)alkoxy;N—(C1-C4)alkylamino;N,N-di-[(C1-C4)alkyl]-amino; orN-arylmethyl-N—(C1-C4)alkyl-amino; R3 represents hydrogen or halogen; R4 represents hydrogen, fluoro, chloro, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkyl-carbonyl, hydroxy-(C1-C4)alkyl, hydroxy-(C2-C4)alkoxy, (C1-C2)alkoxy-(C1-C4)alkyl or (C1-C4)alkoxy-(C2-C4)alkoxy; R5 represents hydrogen or (C1-C4)alkyl; and R6 represents fluoro, chloro, methyl, ethyl or (C1-C2)fluoroalkyl;or a salt of such a compound. |
