| 摘要 |
PROBLEM TO BE SOLVED: To provide a biomarker for predicting an effect of an anti-c-Met antibody and/or selecting a subject for application of an anti-c-Met antibody, a reference marker for gene expression level comparison, and a method for predicting an effect of a c-Met antibody, the method comprising a step of measuring level of the biomarker in a biological sample.SOLUTION: Expression levels of genes in a group on which an anti-c-Met antibody has effects (efficacy group) and in a group on which an anti-c-Met antibody has no effect (non-efficacy group) are compared, and genes showing a great difference are selected. The selected genes or proteins encoded by the genes are suggested as biomarkers for predicting an effect of an anti-c-Met antibody. In addition, genes showing a small or no difference in expression level between different cells or individual cells of a same cell line are selected, and the selected genes or proteins encoded by the genes are suggested as reference biomarkers usable as control for comparison of expression level of a target gene and/or a target protein. |
