| 发明名称 |
NOVEL IL-17A BINDING MOLECULES AND MEDICAL USES THEREOF |
| 摘要 |
The present invention relates to a polypeptide inhibiting the activity of glycosylated IL-17A, wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)(X2)(X3)(X4)(X5)(X6) DLSFHKGEKFQIL STHEYEDWWEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein amino acid positions (X1) to (X6) may be any amino acid sequence; and (b) an amino acid sequence which is at least 85% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X1) to (X6) and provided that the amino acid sequence STHEYE (SEQ ID NO: 2) in amino acid positions 31 to 36 of SEQ ID NO: 1 is conserved. The invention also relates to fusion constructs, compositions and medical uses comprising said polypeptide. |
| 申请公布号 |
US2015322125(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201314428245 |
申请日期 |
2013.09.19 |
| 申请人 |
COVAGEN AG |
发明人 |
SILACCI MELKKO Michela;BANZIGER Nadja;WOODS Richard;ZHA Wenjuan;ATTINGER Isabella;SANTIMARIA Roger;LEMBKE Wibke;BATEY Sarah;VON DER BEY Ulrike;BERTSCHINGER Julian;GRABULOVSKI Dragan |
| 分类号 |
C07K14/47;A61K38/17;C07K16/24 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A polypeptide that inhibits the activity of glycosylated comprising or consisting of an amino acid sequence comprising:
(a)(SEQ ID NO: 1)GVTLEVALYDY(X1)(X2)(X3)(X4)(X5)(X6)DLSFHKGEKFQILSTHEYEDWWEARSLTTGETGYIPSNYVAPVDSIQ,wherein amino acid positions (X1) to (X6) may be any amino acid sequence; or
(b) an amino acid sequence at least 85% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X1) to (X6) and provided that the amino acid sequence STHEYE (SEQ ID NO: 2) in amino acid positions 31 to 36 of SEQ ID NO: 1 is conserved. |
| 地址 |
Zürich-Schlieren CH |
