发明名称 THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
摘要 PROBLEM TO BE SOLVED: To provide compounds for the modulation of blood uric acid levels, and for the treatment of gout or hyperuricemia.SOLUTION: This invention relates to a compound expressed by the formula (I), where Ra and Rb are selected from H, halogen, C1 to C6 alkyl, or the like; M is H, C1-3 alkyl or the like; X1 is N, CH, C(halogen) or the like; X2 is N or CH; X3 is N, CH, C(halogen) or C(C1-C4 alkyl); and X4 is N or CH, wherein at least one of X1 to X4 is N; Y1 is N or CR1; Y2 is N or CR2; R1 is H, CF3, CH3, OCH3, F or Cl; and R2 is H, methyl, ethyl, propyl, isopropyl, tert-butyl, cyclopropyl, cyclobutyl, CF3, OH, OCH3, ethoxy, or the like.
申请公布号 JP2015199760(A) 申请公布日期 2015.11.12
申请号 JP20150120633 申请日期 2015.06.15
申请人 ARDEA BIOSCIENCES INC 发明人 SAMEDY OUK;ESMIR GUNIC;JEAN-MICHEL VERNIER
分类号 C07D213/70;A61K31/426;A61K31/44;A61K31/443;A61K31/4433;A61K31/4439;A61K31/444;A61K31/4709;A61K31/4725;A61K31/4965;A61K31/497;A61K31/502;A61K31/505;A61K31/506;A61K45/00;A61P5/18;A61P9/00;A61P9/10;A61P9/12;A61P13/02;A61P13/04;A61P13/12;A61P17/06;A61P19/02;A61P19/06;A61P35/00;A61P39/02;A61P43/00;C07D239/38;C07D241/18;C07D401/04;C07D403/04;C07D405/04;C07D417/04 主分类号 C07D213/70
代理机构 代理人
主权项
地址