| 发明名称 |
PRODUCTION OF INSULIN PRODUCING CELLS |
| 摘要 |
The invention provides methods for differentiating stem cells along the pancreatic lineage as well as large scale culture methods. The present invention further provides pancreatic progenitor cells derived from stem cells to provide pancreatic cells to a subject. |
| 申请公布号 |
US2015322407(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514715098 |
申请日期 |
2015.05.18 |
| 申请人 |
Regents of the University of Minnesota |
发明人 |
Firpo Meri;Geng Zhaohui |
| 分类号 |
C12N5/071;A61K35/39 |
主分类号 |
C12N5/071 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method to differentiate stem cells to pancreatic progenitor cells comprising the steps of:
a) contacting the stem cells with at least one member of the TGFβ family of cytokines and at least one member of the Wnt family of proteins, b) contacting the cells obtained from step a) with at least one member of the TGFβ family of cytokines, at lesat one member of the Wnt family of proteins, and an agent that inhibits sonic hedgehog activity; and c) contacting the cells obtained from step b) with a member of the Epidermal growth factor (EGF) family of proteins; so as to yield pancreatic progenitor cells. |
| 地址 |
Minneapolis MN US |
