| 发明名称 |
ANTIBODY DRUG CONJUGATES |
| 摘要 |
The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. |
| 申请公布号 |
US2015320880(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514717578 |
申请日期 |
2015.05.20 |
| 申请人 |
ABRAMS Tinya;COHEN Steven Bruce;Fanton Christie P.;FINNER Catrin;HUBER Thomas;Miller Kathy;SCHLEYER Siew Ho;Tissot-Daguette Kathrin Ulrike |
发明人 |
ABRAMS Tinya;COHEN Steven Bruce;Fanton Christie P.;FINNER Catrin;HUBER Thomas;Miller Kathy;SCHLEYER Siew Ho;Tissot-Daguette Kathrin Ulrike |
| 分类号 |
A61K47/48;A61K45/06;C07K16/28 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody drug conjugate of the formula
Ab-(L-(D)m)n or a pharmaceutically acceptable salt thereof; wherein Ab is an antibody or antigen binding fragment thereof that specifically binds to an epitope of human cKIT; L is a linker; D is a drug moiety; m is an integer from 1 to 8; and n is an integer from 1 to 10. |
| 地址 |
Acton MA US |
