| 摘要 |
Methods of promoting neuroblast differentiation in subjects with neuroblastoma by administering an. agent to a subject with neuroblastoma are provided herein. The agent may be a heparin -sulfate proteoglycan co-receptor, heparin sulfate or a heparin analog. Promotion of neuroblast differentiation, may suppress neuroblast growth and treat neuroblastoma... Methods of determining a prognosis for a subject with neuroblastoma are also provided. The methods include measuring the level of at least one marker selected from FGF2, FGFR1, ID1, TβRIII, SDC3, SDC4, GPC3 and GPC1 in a sample from the subject and comparing the level in the subject to a reference level. If the levels of any of the markers are higher than the reference level the subject has a good prognosis. If the levels are lower than the reference level, the prognosis is poor. |
