| 摘要 |
The present application provides a compound for use in the treatment of a subject suffering from itch, wherein said compound is endothelin-converting enzyme (ECE-1), a MEK1 inhibitor, or an ETAR inhibitor. Similarly, these compounds can be used in a topic pharmaceutical composition and for the preparation of a medicament. Also, the present invention provides a method for the screening of a compound useful for the treatment of histamine-independent, endothelin-1 (ET-1)/endothelin A receptor (ETAR) induced itch and a method for diagnosing a subject suffering from a histamine-independent, ET-1/ETAR induced itch. |
