| 发明名称 |
Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
| 摘要 |
<p>The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.</p> |
| 申请公布号 |
AU2013261128(B2) |
申请公布日期 |
2015.11.12 |
| 申请号 |
AU20130261128 |
申请日期 |
2013.05.09 |
| 申请人 |
NOVARTIS AG |
发明人 |
FURET, PASCAL;GROTZFELD, ROBERT MARTIN;JAHNKE, WOLFGANG;JONES, DARRYL BRYNLEY;MANLEY, PAUL;MARZINZIK, ANDREAS;PELLE, XAVIER FRANCOIS ANDRE;SALEM, BAHAA;SCHOEPFER, JOSEPH;SPIESER, ERICH ALOIS |
| 分类号 |
C07D401/14;A61K31/4439;A61K31/444;A61K31/506;A61K31/551;A61P35/00;C07D401/04;C07D401/10;C07D403/10;C07D405/14;C07D413/10;C07D413/14;C07D471/04;C07D487/04;C07D487/10;C07D491/10;C07D498/08 |
主分类号 |
C07D401/14 |
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