PHARMACEUTICAL COMPOSITIONS CONTAINING A DGAT1 INHIBITOR

摘要

The present invention relates to a pharmaceutical composition comprising
a) a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof,b) one or more, e.g. 1, 2 or 3, surfactants with lubricant properties;c) one or more, e.g. 1, 2 or 3, dry binders with disintegrant properties;d) one or more, e.g. 1, 2 or 3, fillers, ande) one or more, e.g. 1, 2 or 3, disintegrants.

主权项

1. A pharmaceutical composition in the form of a tablet comprising
a) a therapeutically effective amount of the sodium salt of the compound trans-(4-{4-[5-(6-trifluromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid b) 0.1 to 5% by weight of the tablet prior to any optional film coating of sodium lauryl sulfate; c) 2 to 20% by weight of the tablet prior to any optional film coating of hydroxypropyl cellulose; d) 15-50% by weight of the tablet prior to any optional film coating of microcrystalline cellulose; e) 0.1-1.0% by weight of the table prior to any optional film coating of colloidal silica; f) 0.1-10% by weight of the table prior to any optional film coating of sodium stearyl fumarate; g) 4 to 85% by weight of the tablet prior to any optional film coating of anhydrous lactose; h) 0.5 to 10% by weight of the tablet prior to any optional film coating of sodium starch glycolate; and i) an optional film coating.