| 发明名称 |
BINDING POLYPEPTIDES WITH OPTIMIZED SCAFFOLDS |
| 摘要 |
The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided. |
| 申请公布号 |
US2015322136(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514812695 |
申请日期 |
2015.07.29 |
| 申请人 |
Genentech, Inc. |
发明人 |
Barthelemy Pierre A.;Sidhu Sachdev S. |
| 分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated antibody variable domain wherein the antibody variable domain comprises one or more amino acid alterations as compared to the naturally-occurring antibody variable domain, and wherein the one or more amino acid alterations increase the stability of the antibody variable domain. |
| 地址 |
South San Francisco CA US |
