发明名称 |
HUMANIZED IL-4 AND IL-4Ra ANIMALS |
摘要 |
Non-human animals comprising a human or humanized IL-4 and/or IL-4Rα nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4Rα gene with a human IL-4 gene and/or IL-4Rα gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4Rα gene under control of non-human IL-4Rα regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4Rα-encoding sequence with human or humanized IL-4Rα-encoding sequence at an endogenous non-human C IL-4Rα locus. Non-human animals comprising human or humanized IL-4 gene and/or IL-4Rα sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided. |
申请公布号 |
US2015320021(A1) |
申请公布日期 |
2015.11.12 |
申请号 |
US201514706319 |
申请日期 |
2015.05.07 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
Wang Li-Hsien;Xue Yingzi;Murphy Andrew;Stevens Sean |
分类号 |
A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. A rodent, comprising a humanization of an endogenous rodent IL-4 gene, wherein the humanization comprises a replacement at the endogenous rodent IL-4 locus of a rodent nucleic acid comprising an exon of an IL-4 gene with a nucleic acid sequence comprising at least one exon of a human IL-4 gene to form a modified IL-4 gene, wherein expression of the modified IL-4 gene is under control of rodent regulatory elements at the endogenous rodent IL-4 locus. |
地址 |
Tarrytown NY US |