| 发明名称 |
TREATMENT OF B-CELL LYMPHOMA WITH MICRORNA |
| 摘要 |
The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL. |
| 申请公布号 |
US2015322430(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201414565049 |
申请日期 |
2014.12.09 |
| 申请人 |
University of Zurich |
发明人 |
Craig Vanessa;Mueller Anne |
| 分类号 |
C12N15/113;A61K45/06;A61K31/7052 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A microRNA for use in the treatment of B-cell lymphoma. |
| 地址 |
Zurich CH |
