主权项 |
1. A compound of formula I or formula II:wherein:
X is (C1-C6)alkyl; Y is (C1-C6)alkyl; R1 is a saturated or unsaturated (C1-C20)alkyl chain that optionally comprises one or more aryl or heteroaryl rings in the chain wherein (C1-C20)alkyl is optionally substituted with one or more halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, NRmRa, or S(O)2NRpRq and wherein any aryl or heteroaryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRaRb, or S(O)2NRcRd; R2 is H or a saturated or unsaturated (C1-C20)alkyl chain that optionally comprises one or more aryl or heteroaryl rings in the chain wherein (C1-C20)alkyl is optionally substituted with one or more halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, NRmRn, or S(O)2NRpRq and wherein any aryl or heteroaryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRaRb, or S(O)2NRcRd; each R3, R4, R5, and R6 is independently OH or (C1-C6)alkoxy; R7 is a saturated or unsaturated (C1-C20)alkyl chain that optionally comprises one or more aryl or heteroaryl rings in the chain wherein (C1-C20)alkyl is optionally substituted with one or more halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, NRmRn, or S(O)2NRpRq and wherein any aryl or heteroaryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRaRb, aryl, heteroaryl, or S(O)2NRcRd; R8 is a saturated or unsaturated (C1-C20)alkyl chain that optionally comprises one or more aryl or heteroaryl rings in the chain wherein (C1-C20)alkyl is optionally substituted with one or more halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, NRmRn, or S(O)2NRpRq and wherein any aryl or heteroaryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRaRb, aryl, heteroaryl, or S(O)2NRcRd; R9 is a saturated or unsaturated (C1-C20)alkyl chain that optionally comprises one or more aryl or heteroaryl rings in the chain wherein (C1-C20)alkyl is optionally substituted with one or more halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, NRmRn, or S(O)2NRpRq and wherein any aryl or heteroaryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRaRb, or S(O)2NRcRd; R10 is H or a saturated or unsaturated (C1-C20)alkyl chain that optionally comprises one or more aryl or heteroaryl rings in the chain wherein (C1-C20)alkyl is optionally substituted with one or more halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, NRmRn, or S(O)2NRpRq and wherein any aryl or heteroaryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRaRb, or S(O)2NRcRd; each Ra and Rb is independently H, (C1-C6)alkyl, or aryl; or Ra and Rb together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each and Rd is independently H, (C1-C6)alkyl, or aryl; or Rc and Rd together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each Rm and Rn is independently H, (C1-C6)alkyl, or aryl; or Rm and Rn together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each Rp and Rq is independently H, (C1-C6)alkyl, or aryl; or Rp and Rq together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; and wherein any aryl of Ra, Rb, Rc, Rd, Rm, Rn, Rp or Rq is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRsRt, or S(O)2NRsRt wherein each Rs and Rt is independently H or (C1-C6)alkyl; or a salt thereof. |