| 主权项 |
1. A compound of general formula I: (wherein Z1 represents an unsaturated, 5- to 7-membered heterocyclic ring, or
a group of the formula —(CH2)x—CO—NH—NH—CO—(CH2)y— wherein x and y independently denote an integer from 0 to 2; Z2 represents an aryl or heteroaryl group optionally substituted by one or more (e.g. 1, 2, 3 or 4) groups Ra;
where each Ra may be identical or different and may be selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (preferably C1-3 alkyl), C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl (e.g. CF3), —CN, —NO2, —OR, —SR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)NR2, —C(O)NR2, —NR2, —NR—C(O)R, —NR—C(O)OR, —S(O)R, —S(O)2R, —S(O)OR or —S(O)2NR2 group (where each R is independently H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl or C2-6 alkynyl); R1 represents an aryl or heteroaryl group optionally substituted by one or more (e.g. 1, 2, 3 or 4) groups Rb;
where each Rb may be identical or different and may be selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (preferably C1-3 alkyl) optionally interrupted by one or more —O—, —S— or —NR— groups (preferably by one or two —O— atoms), C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl (e.g. CF3), —CN, —NO2, —OR, —SR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)NR2, —C(O)NR2, —NR2, —NR—C(O)R, —NR—C(O)OR, —S(O)R, —S(O)2R, —S(O)OR or —S(O)2NR2 group (where each R is independently H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl or C2-6 alkynyl); R2 represents an aryl or heteroaryl group optionally substituted by one or more (e.g. 1, 2, 3 or 4) groups Rc;
where each Rc may be identical or different and may be selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (preferably C1-3 alkyl), C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl (e.g. CF3), —CN, —NO2, —OR, —SR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)NR2, —NR2, —NR—C(O)R, —NR—C(O)OR, —S(O)R, —S(O)2R, —S(O)OR or —S(O)2NR2 group (where each R is independently H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl or C2-6 alkynyl); L1 represents a C1-4 alkylene group optionally substituted by one or more (e.g. 1 or 2) groups Rd, wherein one or more (preferably one or two) methylene groups are each replaced by a group selected from —CRe═CRf—, —C≡C— and —C═C═C—; and
wherein one or more (preferably one to three) methylene groups may each additionally be replaced by a group Y1;where each Y1 is independently selected from —O—, —S—, —NH—, —NR′″—, —NR′″-C(O)—, —C(O)—NR′″—, —C(O)—, —S(O2)—, —S(O)— and —CR′″═N— (where each R′″ is independently hydrogen or C1-6 alkyl);where each Rd may be identical or different and may be selected from C1-6 alkyl (preferably C1-3 alkyl), hydroxy, C1-6 alkoxy (e.g. C1-3 alkoxy) and halogen (i.e. F, Cl, Br and I, preferably F); andwhere Re and Rf are independently selected from H, C1-3 alkyl, halogen (e.g. F or Cl), C1-3 haloalkyl (e.g. —CF3), —CN, —NO2, —OR, —SR, —C(O)R, —C(O)OR, —OC(O)R, —OPO3R, —OSO2R and —OSiR4 (where each R is independently H, C1-6 alkyl or C1-6 haloalkyl); L2 represents a bond or an optionally substituted C1-6 alkylene group; and L3 represents a bond or an optionally substituted C1-6 alkylene group) or an isomer (e.g. stereoisomer), pharmaceutically acceptable salt or prodrug thereof. |
