THERAPEUTIC CATECHOLS

摘要

The invention provides compounds of formula I:;;and salts thereof wherein R1-R4 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts, and methods for their use in therapy. The compounds have useful antiviral properties.

主权项

1. A compound of formula (I):wherein:
R1 is H or NO2; one of R2 and R3 is Ra; and the other of R2 and R3 is phenyl, naphthyl, or a 5-6 membered heteroaryl, wherein any phenyl, naphthyl, and 5-6 membered heteroaryl is optionally substituted with one or more Rb; R4 is H or (C1-C4)alkyl that is optionally substituted with one or more Rd; Ra is H, halo, aryl, heteroaryl, aryl(C1-C4)alkyl, heteroaryl(C1-C4)alkyl, or (C1-C6)alkyl, wherein any aryl and heteroaryl is optionally substituted with one or more Rc, and wherein any (C1-C4)alkyl and (C1-C6)alkyl is optionally substituted with one or more Rk; each Rb is independently selected from the group consisting of halo, hydroxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, cyano, tetrazole, carboxy, phenyl, naphthyl, —NReRf, —C(═O)NReRf, and nitro, wherein each (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, naphthyl, and (C1-C6)alkoxy, are optionally substituted with one or more groups independently selected from halo, hydroxy, —NReRf, carboxy, heterocycle, and —C(═O)NReRf; each Rc is independently selected from the group consisting of halo, hydroxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, cyano, aryl, heteroaryl, and nitro, wherein each (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, and (C1-C6)alkoxy, are optionally substituted with one or more groups independently selected from halo, hydroxy, —NReRf, carboxy, heterocycle, and —C(═O)NReRf, and wherein any aryl and heteroaryl is optionally substituted with one or more groups independently selected from halo, hydroxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, cyano, tetrazole, nitro, —NReRf, carboxy, heterocycle, and —C(═O)NReRf; each Rd is independently selected from the group consisting of halo, hydroxy, cyano, carboxy, heterocycle, —NReRf, and —C(═O)NReRf; each Re and Rf is independently selected from hydrogen, (C1-C6)alkyl, and (C1-C6)alkanoyl; or Re and Rf together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; and each Rk is independently selected from the group consisting of hydroxy, (C1-C6)alkyl, carboxy, and —C(═O)NReRf, wherein each (C1-C6)alkyl is optionally substituted with one or more groups independently selected from halo, hydroxy, —NReRf, cyano, carboxy, and —C(═O)NReRf; or a salt or prodrug thereof.