发明名称 METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA
摘要 A method for modulating RNA with tetracycline compounds is described.
申请公布号 US2015321997(A1) 申请公布日期 2015.11.12
申请号 US201514790179 申请日期 2015.07.02
申请人 Paratek Pharmaceuticals, Inc. 发明人 Levy Stuart B.;Draper Michael P.;Nelson Mark L.;Jones Graham
分类号 C07C237/26 主分类号 C07C237/26
代理机构 代理人
主权项 1. A compound of the following formula, or a pharmaceutically acceptable salt, ester, or enantiomer thereof: wherein: R7 is halogen;R9 is —(CH2)0-3NR9cC(═Z′)ZR9a;Z′ is O, S, or NR9f;Z is CR9dR9e, S, NR9b, or O; and,R9a, R9b, R9c, R9d, R9e, and R9f are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic, or a prodrug moiety.
地址 Boston MA US